EMEKA AKAMIKE######################################################
THE FOLLOWING BOOKS ARE COMING SOON:
1. AMIDES AND ESTERS IN DRUG DISCOVERY BY EMEKA AKAMIKE
This manuscript explores the role of amides and esters in drug discovery
2. ANTIMALARIA DRUGS PATTERN IN DRUG DISCOVERY Part one BY EMEKA AKAMIKE
A statistical review of anti-malaria drugs
This manuscript is a review of the evolution of malaria and anti-malaria drugs, a statistical and chemical analysis of anti-malarial drugs to identify patterns and violations of Lipsinki rule of five (Ro5). It proposes the next generation of anti-malarial drugs. The calculations for statistical analysis were done for parameters such as cLog P, parachor, polarizability, molar refractivity, druglikeness, etc. It reviews the control of malaria that includes biochemical, chemical, structural and pattern analysis of insecticides.
3. BIO-ENERGY COMPOUNDS PATTERNS-Part 1 BY EMEKA AKAMIKE
ATP AND ATP DERIVATIVES/VITAMINS
This manuscript is a computer-aided analysis of a whole array of energy sources in the human body and their bioactivity/molecular properties patterns. The relationship of antioxidants to longevity, various diseases such as cardiovascular disease, arthritis, COPD, Parkinson’s disease, and cystic acne is explored including their effect on physical exercise. Fatty acids antioxidant properties are compared to the hypothetical substituted derivatives to expose a unique pattern. The effect of antioxidants on free radicals is illustrated with the drug edaravone, a free radical scavenger, on Parkinson’s disease. Free radical induced oxidative stress is involved in the mechanisms of cell death in Parkinson’s disease, and edaravone exerts a neuroprotective effects on Parkinson disease. The antioxidant properties of food additives are reviewed. Compounds such as anthocyanins, glutathione, uric acid, ubiquinones, melatonin, caffeine and the coenzymes A & Q series display characteristic pattern including blood thinners.
4. DRUG PATTERNS IN DRUG DISCOVERY –Part 1 BY EMEKA A. AKAMIKE
This manuscript explores the statistical relationships between the physicochemical parameters (clog P, parachor, molecular weight, molar volume, polarizability, molar refractivity, PSA, log BB, druglikeness, and calculated formula weight, CFW), and bioactivity data in the five therapeutic areas (anticholesterol drugs (STATINS), antiretroviral (ARV), central nervous system (CNS), steroids, and mustards. Finally, it predicts the next generation of nitrogen mustards.
A statistical evaluation
5. DRUG DISCOVERY CHEMISTRY: THE NEXT GENERATION OF NITROGEN MUSTARDS AS ANTI-CANCER AGENTS BY EMEKA AKAMIKE
This book is an applied medicinal chemistry approach to the design and prediction of the next generation of nitrogen mustards that involves the application and use of some of the computer chemistry softwares. It undertakes the statistical analysis of the molecular parameters such as clog P, molar refractivity, molar volume, parachor, TPSA, and polarizability. These parameters are correlated to the bioactivity properties such as GPCR, ion channel, kinase inhibition, nuclear receptor inhibition, protease and enzyme inhibition. The mathematical evaluation of the additivity of molecular components is compared to their bioactivities. These instruments of analysis are used to evaluate the druglikeness of the proposed novel nitrogen mustards.
6. MORPHINE. PAIN KILLER: PATTERNS IN DRUG DISCOVERY Part one. BY EMEKA AKAMIKE
This manuscript is a computer-aided review of the molecular and bioactivity properties of commercially available morphine and morphine analogs using descriptors. Since the laboratory synthesis of morphine is challenging, alternative novel chromophore is proposed and analyzed. Morphine metabolism is reviewed. The ability of these compounds to cross the blood brain-barrier is calculated. A detailed statistical analysis is carried. The hybrids of morphine and novel chromophore are formed with compounds such as serotonin, histamine, sulfonamides, tapentadol, eticyclidine, Quaalude, ampakine, NMDA ligands, kainic acid , talampanel, pethidine, etc.
7. SELECT MORPHINE HYBRIDS AND NOVEL CHROMOPHORE BY EMEKA AKAMIKE
An elaborate comparison of the physical and bioactivity properties of proposed morphine hybrids and derivatives with the corresponding novel chromophore hybrids. Using Corydalis extracts/analogs as reference compounds, major bioactivity differences are identified when compared to opiates, morphine, codeine, and heroin.
