CURRENT GLOBAL BOOK REVIEWS

EMEKA AKAMIKE###################################################### THE FOLLOWING BOOKS ARE COMING SOON: 1. AMIDES AND ESTERS IN DRUG DISCOVERY BY EMEKA AKAMIKE This manuscript explores the role of amides and esters in drug discovery 2. ANTIMALARIA DRUGS PATTERN IN DRUG DISCOVERY Part one BY EMEKA AKAMIKE A statistical review of anti-malaria drugs This manuscript is a review of the evolution of malaria and anti-malaria drugs, a statistical and chemical analysis of anti-malarial drugs to identify patterns and violations of Lipsinki rule of five (Ro5). It proposes the next generation of anti-malarial drugs. The calculations for statistical analysis were done for parameters such as cLog P, parachor, polarizability, molar refractivity, druglikeness, etc. It reviews the control of malaria that includes biochemical, chemical, structural and pattern analysis of insecticides. 3. BIO-ENERGY COMPOUNDS PATTERNS-Part 1 BY EMEKA AKAMIKE ATP AND ATP DERIVATIVES/VITAMINS This manuscript is a computer-aided analysis of a whole array of energy sources in the human body and their bioactivity/molecular properties patterns. The relationship of antioxidants to longevity, various diseases such as cardiovascular disease, arthritis, COPD, Parkinson’s disease, and cystic acne is explored including their effect on physical exercise. Fatty acids antioxidant properties are compared to the hypothetical substituted derivatives to expose a unique pattern. The effect of antioxidants on free radicals is illustrated with the drug edaravone, a free radical scavenger, on Parkinson’s disease. Free radical induced oxidative stress is involved in the mechanisms of cell death in Parkinson’s disease, and edaravone exerts a neuroprotective effects on Parkinson disease. The antioxidant properties of food additives are reviewed. Compounds such as anthocyanins, glutathione, uric acid, ubiquinones, melatonin, caffeine and the coenzymes A & Q series display characteristic pattern including blood thinners.  4. DRUG PATTERNS IN DRUG DISCOVERY –Part 1 BY EMEKA A. AKAMIKE This manuscript explores the statistical relationships between the physicochemical parameters (clog P, parachor, molecular weight, molar volume, polarizability, molar refractivity, PSA, log BB, druglikeness, and calculated formula weight, CFW), and bioactivity data in the five therapeutic areas (anticholesterol drugs (STATINS), antiretroviral (ARV), central nervous system (CNS), steroids, and mustards. Finally, it predicts the next generation of nitrogen mustards. A statistical evaluation 5. DRUG DISCOVERY CHEMISTRY: THE NEXT GENERATION OF NITROGEN MUSTARDS AS ANTI-CANCER AGENTS BY EMEKA AKAMIKE This book is an applied medicinal chemistry approach to the design and prediction of the next generation of nitrogen mustards that involves the application and use of some of the computer chemistry softwares. It undertakes the statistical analysis of the molecular parameters such as clog P, molar refractivity, molar volume, parachor, TPSA, and polarizability. These parameters are correlated to the bioactivity properties such as GPCR, ion channel, kinase inhibition, nuclear receptor inhibition, protease and enzyme inhibition. The mathematical evaluation of the additivity of molecular components is compared to their bioactivities. These instruments of analysis are used to evaluate the druglikeness of the proposed novel nitrogen mustards. 6. MORPHINE. PAIN KILLER: PATTERNS IN DRUG DISCOVERY Part one. BY EMEKA AKAMIKE This manuscript is a computer-aided review of the molecular and bioactivity properties of commercially available morphine and morphine analogs using descriptors. Since the laboratory synthesis of morphine is challenging, alternative novel chromophore is proposed and analyzed. Morphine metabolism is reviewed. The ability of these compounds to cross the blood brain-barrier is calculated. A detailed statistical analysis is carried. The hybrids of morphine and novel chromophore are formed with compounds such as serotonin, histamine, sulfonamides, tapentadol, eticyclidine, Quaalude, ampakine, NMDA ligands, kainic acid , talampanel, pethidine, etc. 7. SELECT MORPHINE HYBRIDS AND NOVEL CHROMOPHORE BY EMEKA AKAMIKE An elaborate comparison of the physical and bioactivity properties of proposed morphine hybrids and derivatives with the corresponding novel chromophore hybrids. Using Corydalis extracts/analogs as reference compounds, major bioactivity differences are identified when compared to opiates, morphine, codeine, and heroin.

SOFT TISSUE - A BREAST CANCER NOVEL; AND SCALPEL - HIV/AIDS NOVEL

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Soft Tissue, novel on Breast Cancer $16.00

SOFT TISSUE,

A THRILLING NOVEL ON BREAST CANCER. $16.00

Available (0nline):
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Soft Tissue by N. A. Akamike, ISBN #: 978-0-8059-8446-0

Soft Tissue: The Unsolved Mystery, Breast Cancer” is a fictitious story that blends aspects of medical and sociological drama creating a contemporary, thrilling, fast paced and engaging novel.
The story begins with Roxy Adams striking a friendship with Elaine, Ifeoma, and Beatrice during the Chicago’s mayoral election. Their friendship culminated in a vacation to Egypt. Roxy, the daughter of an industrialist father whose wife has a genetic link to cancer, fell in love with James Ugo, a scientist, en route to Egypt. A romantic relationship developed between James and Roxy that continued after the end of the Egyptian vacation. Her relationship with James headed towards marriage. The interests and professional ties of Roxy, an attorney, and her friends provided a forum for an extensive discussion of breast cancer. The scientist and medical doctors elaborated on most aspects of the cancer, possible risk factors, including oral contraceptives and hormone based therapies. When Roxy was suddenly diagnosed with breast cancer, her curiosity about the origin and progress of breast cancer expanded the conversation to include considerations of stem cell research and genetic influences. The diagnosis exposed the fragility of the love between Roxy and James. The emotional turmoil as a result of the diagnosis compounded by potential infidelity by James caused Roxy to have an accident. On the other hand, Denise who suffered a stroke as a consequence of HRT use faced uncertainty in her proposed marriage to her long term fiancé, Charles.
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About the Author:

N. A. Akamike is a research scientist in the areas of industrial chemistry and medicinal chemistry, emphasizing in pharmaceutical sciences. He is a recipient of the Sigma Xi Award (excellence in science), the inventor on four patents related to cancer (World Patent, U.S. Patent, European Patent), and the coauthor of eight scientific publications in the area of cancer and HIV/AIDS. Akamike is a staff scientist in drug discovery with major pharmaceutical companies, including Biotechs in the San Francisco Bay area.

Cover design by Dan Fagan

ISBN: 978-0-8059-8446-0

Publisher: RED LEAD PRESS 701 SMITHFIELD STREET, THIRD FLOOR PITTSBURGH, PA 15222
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Patents: (1996) Issued: European Patent No. EP705250A1
Bis-imide Polycyclic and Heterocyclic Chromophores useful as tumoricidals
AD. Patten, GJ. Pacofsky, SP. Seitz, EA. Akamike, RJ. Cheney,
RF. Kaltenbach, MJ. Orwat.

(1996) Issued: U.S. Patent No. 5,585,382
Polycyclic and Heteroaromatic Chromophores for bis-imides Tumoricidals
AD. Patten, GJ. Pacofsky, SP. Seitz, EA. Akamike, RJ. Cheney,
RF. Kaltenbach, MJ. Orwat.

(1995) Issued: World Patent No. WO9500490A1
Bis-imide Polycyclic and Heterocyclic Chromophores useful as tumoricidals
AD. Patten, GJ. Pacofsky, SP. Seitz, EA. Akamike, RJ. Cheney,
RF. Kaltenbach, MJ. Orwat.

(1995) Issued: U. S. Patent No. 5,416,089
Bis-imide Polycyclic and Heteroaromatic Chromophores for Bis-imide
tumoricidals
EA. Akamike, RJ. Cheney, RF. Kaltenbach, MJ. Orwat. GJ. Pacofsky,
AD. Patten, SP. Seitz

Publications: Carini, D. J., Kaltenbach, R. F., Liu, J., Benfield, P. A., Boylan, J., Boisclair, M.,
Brizuela, L., Burton, C. R., Cox, S., Grafstrom, R., Harrison, B. A., Harrison, K.,
Akamike, E., Markwalder, J. A., Nakano, Y., Seitz, S. P., Sharp, D. M.,
Trainor, G. L., Sielecki, T. M.,
Identification of Selective Inhibitors of Cyclin Dependent Kinase 4
Bioorganic & Medicinal Chemistry Letters, 2001, vol. 11, No. 2, pages 209-11

Robert J. Cheney, Stephen G. Swartz, Arthur D. Patten, Emeka A. Akamike,
Jung-Hui Sun, Robert F. Kaltenbach III, George L. Trainor, Mike Vavala, et. al.
The DuPont Merck Pharmaceutical Co., Wilmington, DE, U. S. A
The Synthesis and Antitumor Evaluation of Unsymmetrical Bis-imides.
Biorganic & Medicinal Chemistry Letters, 1997, vol. 7, No. 2, pages 163-168

De Lucca, George V.; Kim, Ui T.; Akamike, Emeka A.; Lam, Patrick;
Clark, Charles; Rodgers, James; Wang, Haisheng; Ko, Soo; Srivastava, Anurug;
et.al
The DuPont Merck Pharmaceutical Co., Wilmington, DE U. S. A.
Structure Activity Relationship of Cyclic Ureas With Asymmetric P2/P2'
substituents: Potent Inhibitors of HIV-1 Protease
American Chemical Society, Division of Medicinal Chemistry, April 13-17, 1997

Wendell W. Wilkerson, Emeka A. Akamike, Walter W. Cheatham, Dale C. Collins,
Andrea Y. Hollis: The DuPont Merck Pharmaceutical Co., Wilmington, DE
HIV Protease Inhibitory Bis-benzamide Cyclic Ureas: A Quantitative Structure-
Activity Relationship Analysis,
Journal Of Medicinal Chemistry, 1996, vol. 39, No. 21, pages 4299-4312

Micheal T. Furlong, Hanley N. Abramson, Nnaemeka A. Akamike, and Henry C.
Wormser: Approach To Aminated Anthracyclines via Intramolecular Marschalk
Reaction.;
Synthetic Communications, 20(17), 2691 -2697, (1990)

Abramson, H. N., Akamike, N. A., Banning, J. W., Natchman, J. P., Nagia, Z. M,
Wormser, H. C.: Synthesis and Biological Evaluation of Certain 1- and
1,4- substituted Anthraquinones.
The Pharmacologists. (1985), 27, No. 3, 109

Akamike, N. A., Abramson, H. N., Wormser, H. C., Sardessai, M. S.,
A Novel Method For the Displacement of Halogen At The 1-position of
Anthraquinones By Acetamides.
American Chemical Society, Division of Organic Chemistry, April 22, 1990

Furlong, M. T., Abramson, H. N., Akamike, N. A., Wormser, H. C.;
Synthesis of Aminated Daunomycin Analogs Via Intramolecular Marschalk
Reaction.
American Chemical Society, Division of Medicinal Chemistry, April 22,1990

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